2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158943
    2-Fluoro QMPSB 2707165-48-6 98%
    2-Fluoro QMPSB (QMDFPSB) is structurally similar to known synthetic cannabinoids.
    2-Fluoro QMPSB
  • HY-158947
    1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE 1199257-33-4 98%
    1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE (compound 18) is a lipid metabolite associated with central nervous system diseases.
    1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE
  • HY-158967
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride 2740551-86-2 98%
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride is a utopioid.
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride
  • HY-159126
    SIRT2-IN-15 312275-43-7 98%
    SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC50 7 and 37 μM, respectively.
    SIRT2-IN-15
  • HY-159689
    Cloroperone 61764-61-2 98%
    Cloroperone is a 5-HT2 receptor inhibitor with a Ki value of 4.5 nM. Cloroperone can be used in research on psychiatric disorders.
    Cloroperone
  • HY-15981R
    Omarigliptin (Standard) 1226781-44-7 98%
    Omarigliptin (Standard) is the analytical standard of Omarigliptin. This product is intended for research and analytical applications. Omarigliptin (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. Omarigliptin shows anti-parkinsonian activity. Omarigliptin has the neuroprotective effect to improve diabetes-associated cognitive dysfunction.
    Omarigliptin (Standard)
  • HY-159842
    Fosrolapitant 2573694-38-7 98%
    Fosrolapitant is a neurokinin 1 (NK1) receptor antagonist.
    Fosrolapitant
  • HY-159848
    Nedemelteon 1000334-38-2 98%
    Nedemelteon is a melatonin receptor agonist.
    Nedemelteon
  • HY-160037
    SEW06622 261349-28-4 98%
    SEW06622 is a BACE-1 inhibitor with an IC50 value of 6.3 μM and can be used in Alzheimer's disease research.
    SEW06622
  • HY-160092
    Martinostat 1629052-58-9 98%
    Martinostat is a HDAC inhibitor and can be labeled with radionuclides for quantitative imaging of HDACs in vivo in the central nervous system and major peripheral organs.
    Martinostat
  • HY-160105
    GABAB receptor antagonist 3 160415-40-7 98%
    GABAB receptor antagonist 3 (example 3) is a antagonist of GABAB receptor.
    GABAB receptor antagonist 3
  • HY-160446
    BET-IN-24 2407658-21-1 98%
    Bet-in-24 (example 2) is a bromodomain and extra-terminal (BET) inhibitor. BET-IN-24 can be used in the study of virology, heart failure, inflammation, central nervous system (CNS) diseases and many cancers
    BET-IN-24
  • HY-160612
    Transthyretin-IN-2 4664-62-4 98%
    Transthyretin-IN-2 (Compound 36) is a transthyretin (TTR) amyloidsis inhibitor, with IC50 and pIC50 values of 1.31 μM and 5.88 μM. Transthyretin-IN-2 can be used for the research of TTR amyloidosis diseases.
    Transthyretin-IN-2
  • HY-160931
    NMDA receptor modulator 8 1629853-49-1 98%
    NMDA receptor modulator 8 (Compound 3-6) is a modulator for NMDA receptor, with 50%-100% potentiation of NMDA receptor at 10 μM.
    NMDA receptor modulator 8
  • HY-161029
    T14-A24 98%
    T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile.
    T14-A24
  • HY-161062
    TAOA AM Ester trimethyl lock 98%
    TAOA AM Ester trimethyl lock is a high-affinity fluorescent prodrug-like inhibitor of the excitatory amino acid transporter (EAAT). It can penetrate the cell membrane and be activated by hydrolysis by endogenous cell esterases to form active EAAT inhibitors. TAOA AM Ester trimethyl lock can be used to study neurodegeneration and neuronal cell death.
    TAOA AM Ester trimethyl lock
  • HY-161118
    MB327 61368-98-7 98%
    MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning.
    MB327
  • HY-161163
    IND 1316 1888473-12-8 98%
    IND 1316 is an orally active, blood-brain barrier permeable AMPK activator with neuroprotective effects in animal models of Huntington's disease. IND 1316 can be used for research on neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
    IND 1316
  • HY-161382
    NPFF2-R ligand 1 98%
    NPFF2-R ligand 1 (Compound 16a) is a NPFF2-R ligand, with Kis of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system.
    NPFF2-R ligand 1
  • HY-161913
    AC-4-248 98%
    AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively.
    AC-4-248
Cat. No. Product Name / Synonyms Application Reactivity